Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways
نویسندگان
چکیده
منابع مشابه
Conformational adaptation in drug-target interactions and residence time.
Although drug-target interactions are commonly illustrated in terms of structurally static binding and dissociation events, such descriptions are inadequate to explain the impact of conformational dynamics on these processes. For high-affinity interactions, both the association and dissociation of drug molecules to and from their targets are often controlled by conformational changes of the tar...
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ژورنال
عنوان ژورنال: ACS Central Science
سال: 2019
ISSN: 2374-7943,2374-7951
DOI: 10.1021/acscentsci.9b00770